| A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole) |
cancer |
| Acetaldehyde |
cancer |
| Acetamide |
cancer |
| Acetazolamide |
developmental |
| Acetochlor |
cancer |
| Acetohydroxamic acid |
developmental |
| 2-Acetylaminofluorene |
cancer |
| Acifluorfen sodium |
cancer |
| Acrylamide |
cancer |
| Acrylamide |
developmental, male |
| Acrylonitrile |
cancer |
| Actinomycin D [Basis for listing changed effective February 22, 2013] |
cancer |
| Actinomycin D |
developmental |
| AF-2;[2-(2-furyl)-3-(5-nitro-2-furyl)]acrylamide |
cancer |
| Aflatoxins |
cancer |
| Alachlor |
cancer |
| Alcoholic beverages, when associated with alcohol abuse |
cancer |
| Aldrin |
cancer |
| All-trans retinoic acid |
developmental |
| Allyl chloride Delisted October 29, 1999 [Click here for the basis for delisting] |
cancer |
| Alprazolam |
developmental |
| Altretamine |
developmental, male |
| Amantadine hydrochloride |
developmental |
| Amikacin sulfate |
developmental |
| 2-Aminoanthraquinone |
cancer |
| p-Aminoazobenzene |
cancer |
| o-Aminoazotoluene |
cancer |
| 4-Aminobiphenyl (4-aminodiphenyl) |
cancer |
| 1-Amino-2,4-dibromoanthraquinone |
cancer |
| 3-Amino-9-ethylcarbazole hydrochloride |
cancer |
| 2-Aminofluorene |
cancer |
| Aminoglutethimide |
developmental |
| Aminoglycosides |
developmental |
| 1-Amino-2-methylanthraquinone |
cancer |
| 2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole |
cancer |
| 4-Amino-2-nitrophenol |
cancer |
| Aminopterin |
developmental, female |
| Amiodarone hydrochloride |
developmental, female, male |
| Amitraz |
developmental |
| Amitrole |
cancer |
| Amoxapine |
developmental |
| Amsacrine |
cancer |
| tert-Amyl methyl ether Delisted December 13, 2013 [Click here for the basis for delisting] |
developmental |
| Anabolic steroids |
female, male |
| Analgesic mixtures containing Phenacetin |
cancer |
| Androstenedione |
cancer |
| Angiotensin converting enzyme (ACE) inhibitors |
developmental |
| Aniline |
cancer |
| Aniline hydrochloride |
cancer |
| o-Anisidine |
cancer |
| o-Anisidine hydrochloride |
cancer |
| Anisindione |
developmental |
| Anthraquinone |
cancer |
| Antimony oxide (Antimony trioxide) |
cancer |
| Aramite |
cancer |
| Areca nut |
cancer |
| Aristolochic acids |
cancer |
| Arsenic (inorganic arsenic compounds) |
cancer |
| Arsenic (inorganic oxides) |
developmental |
| Asbestos |
cancer |
| Aspirin (NOTE: It is especially important not to use aspirin during the last three months of pregnancy, unless specifically directed to do so by a physician because it may cause problems in the unborn child or complications during delivery.) |
developmental, female |
| Atenolol |
developmental |
| Auramine |
cancer |
| Auranofin |
developmental |
| Avermectin B1 (Abamectin) |
developmental |
| Azacitidine |
cancer |
| Azaserine |
cancer |
| Azathioprine |
cancer |
| Azathioprine |
developmental |
| Azobenzene |
cancer |
|
|
| Barbiturates |
developmental |
| Beclomethasone dipropionate |
developmental |
| Benomyl |
developmental, male |
| Benthiavalicarb-isopropyl |
cancer |
| Benz[a]anthracene |
cancer |
| Benzene |
cancer |
| Benzene |
developmental, male |
| Benzidine [and its salts] |
cancer |
| Benzidine-based dyes |
cancer |
| Benzodiazepines |
developmental |
| Benzo[b]fluoranthene |
cancer |
| Benzo[j]fluoranthene |
cancer |
| Benzo[k]fluoranthene |
cancer |
| Benzofuran |
cancer |
| Benzophenone |
cancer |
| Benzo[a]pyrene |
cancer |
| Benzotrichloride |
cancer |
| Benzphetamine hydrochloride |
developmental |
| Benzyl chloride |
cancer |
| Benzyl violet 4B |
cancer |
| Beryllium and beryllium compounds |
cancer |
| Beryllium |
|
| Beryllium oxide |
|
| Beryllium sulfate |
|
| Betel quid with tobacco |
cancer |
| Betel quid without tobacco |
cancer |
| 2,2-Bis(bromomethyl)-1,3-propanediol |
cancer |
| Bis(2-chloroethyl)ether |
cancer |
| N,N-Bis(2-chloroethyl)-2-naphthylamine (Chlornapazine) |
cancer |
| Bischloroethyl nitrosourea (BCNU) (Carmustine) |
cancer |
| Bischloroethyl nitrosourea (BCNU) (Carmustine) |
developmental |
| Bis(chloromethyl)ether |
cancer |
| Bis(2-chloro-1-methylethyl)ether, technical grade |
cancer |
| Bisphenol A (BPA) Delisted April 19, 2013 [Click here for the basis for delisting] |
developmental |
| Bitumens, extracts of steam-refined and air refined |
cancer |
| Bracken fern |
cancer |
| Bromacil lithium salt |
developmental |
| Bromacil lithium salt |
male |
| Bromate |
cancer |
| Bromochloroacetic acid |
cancer |
| Bromodichloromethane |
cancer |
| Bromoethane |
cancer |
| Bromoform |
cancer |
| 1-Bromopropane (1-BP) |
developmental, female, male |
| 2-Bromopropane (2-BP) |
female, male |
| Bromoxynil |
developmental |
| Bromoxynil octanoate |
developmental |
| Butabarbital sodium |
developmental |
| 1,3-Butadiene |
cancer |
| 1,3-Butadiene |
developmental, female, male |
| 1,4-Butanediol dimethanesulfonate (Busulfan) |
cancer |
| 1,4-Butanediol dimethanesulfonate (Busulfan) |
developmental |
| Butylated hydroxyanisole |
cancer |
| Butyl benzyl phthalate (BBP)d |
developmental |
| n-Butyl glycidyl ether Delisted April 4, 2014 [Click here for the basis for delisting] |
male |
| beta-Butyrolactone |
cancer |
|
|
| Cacodylic acid |
cancer |
| Cadmium |
developmental, male |
| Cadmium and cadmium compounds |
cancer |
| Cadmium |
|
| Caffeic acid |
cancer |
| Captafol |
cancer |
| Captan |
cancer |
| Carbamazepine |
developmental |
| Carbaryl |
cancer |
| Carbaryl [Basis for listing changed effective December 27, 2013] |
developmental, female, male |
| Carbazole |
cancer |
| Carbon black (airborne, unbound particles of respirable size) |
cancer |
| Carbon disulfide |
developmental, female, male |
| Carbon monoxide |
developmental |
| Carbon tetrachloride |
cancer |
| Carbon-black extracts |
cancer |
| Carboplatin |
developmental |
| N-Carboxymethyl-N-nitrosourea |
cancer |
| Catechol |
cancer |
| Ceramic fibers (airborne particles of respirable size) |
cancer |
| Certain combined chemotherapy for lymphomas |
cancer |
| Chenodiol |
developmental |
| Chloral |
cancer |
| Chloral hydrate |
cancer |
| Chlorambucil |
cancer |
| Chlorambucil |
developmental |
| Chloramphenicol Delisted January 4, 2013 [Click here for the basis for delisting] |
cancer |
| Chloramphenicol sodium succinate |
cancer |
| Chlorcyclizine hydrochloride |
developmental |
| Chlordane |
cancer |
| Chlordecone (Kepone) |
cancer |
| Chlordecone (Kepone) |
developmental |
| Chlordiazepoxide |
developmental |
| Chlordiazepoxide hydrochloride |
developmental |
| Chlordimeform |
cancer |
| Chlorendic acid |
cancer |
| Chlorinated paraffins (Average chain length, C12;approximately 60 percent chlorine by weight) |
cancer |
| p-Chloroaniline |
cancer |
| p-Chloroaniline hydrochloride |
cancer |
| Chlorodibromomethane Delisted October 29, 1999 [Click here for the basis for delisting] |
cancer |
| Chloroethane (Ethyl chloride) |
cancer |
| 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) |
cancer |
| 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) |
developmental |
| 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (Methyl-CCNU) |
cancer |
| Chloroform |
cancer |
| Chloroform |
developmental |
| Chloromethyl methyl ether (technical grade) |
cancer |
| 3-Chloro-2-methylpropene |
cancer |
| 1-Chloro-4-nitrobenzene |
cancer |
| 4-Chloro-o-phenylenediamine |
cancer |
| Chloroprene |
cancer |
| 2-Chloropropionic acid [Basis for listing changed effective December 20, 2013] |
male |
| Chlorothalonil |
cancer |
| p-Chloro-o-toluidine |
cancer |
| p-Chloro-o-toluidine, strong acid salts of |
cancer |
| p-Chloro-o-toluidine, hydrochloride |
|
| 5-Chloro-o-toluidine and its strong acid salts |
cancer |
| Chlorotrianisene |
cancer |
| Chlorozotocin |
cancer |
| Chlorsulfuron Delisted June 6, 2014 [Click here for the basis for delisting] |
developmental, female, male |
| Chromium (hexavalent compounds) |
cancer |
| Chromium (hexavalent compounds) |
developmental, female, male |
| Chrysene |
cancer |
| C.I. Acid Red 114 |
cancer |
| C.I. Basic Red 9 monohydrochloride |
cancer |
| C.I. Direct Blue 15 |
cancer |
| C.I. Direct Blue 218 |
cancer |
| C.I. Disperse Yellow 3 |
cancer |
| C.I. Solvent Yellow 14 |
cancer |
| Ciclosporin (Cyclosporin A; Cyclosporine) |
cancer |
| Cidofovir |
cancer, developmental, female, male |
| Cinnamyl anthranilate |
cancer |
| Cisplatin |
cancer |
| Citrus Red No. 2 |
cancer |
| Cladribine |
developmental |
| Clarithromycin |
developmental |
| Clobetasol propionate |
developmental, female |
| Clofibrate |
cancer |
| Clomiphene citrate |
cancer |
| Clomiphene citrate |
developmental |
| Clorazepate dipotassium |
developmental |
| Cobalt metal powder |
cancer |
| Cobalt [II] oxide |
cancer |
| Cobalt sulfate |
cancer |
| Cobalt sulfate heptahydrate |
cancer |
| Cocaine |
developmental, female |
| Coconut oil diethanolamine condensate (cocamide diethanolamine) |
cancer |
| Codeine phosphate |
developmental |
| Coke oven emissions |
cancer |
| Colchicine |
developmental, male |
| Conjugated estrogens |
cancer |
| Conjugated estrogens |
developmental |
| Creosotes |
cancer |
| p-Cresidine |
cancer |
| Cumene |
cancer |
| Cupferron |
cancer |
| Cyanazine |
developmental |
| Cycasin |
cancer |
| Cycloate |
developmental |
| Cyclohexanol Delisted January 25, 2002 [Click here for the basis for delisting] |
male |
| Cycloheximide |
developmental |
| Cyclopenta[cd]pyrene |
cancer |
| Cyclophosphamide (anhydrous) |
cancer |
| Cyclophosphamide (anhydrous) |
developmental, female, male |
| Cyclophosphamide (hydrated) |
cancer |
| Cyclophosphamide (hydrated) |
developmental, female, male |
| Cyhexatin |
developmental |
| Cytarabine |
developmental |
| Cytembena |
cancer |
|
|
| D&C Orange No. 17 |
cancer |
| D&C Red No. 8 |
cancer |
| D&C Red No. 9 |
cancer |
| D&C Red No. 19 |
cancer |
| Dacarbazine |
cancer |
| Dacarbazine |
developmental |
| Daminozide |
cancer |
| Danazol |
developmental |
| Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone) |
cancer |
| Daunomycin |
cancer |
| Daunorubicin hydrochloride |
developmental |
| 2,4-D butyric acid [Click here for the basis for the removal of developmental endpoint, effective June 22, 2001] |
developmental, male |
| DDD (Dichlorodiphenyl-dichloroethane) |
cancer |
| DDE (Dichlorodiphenyl-dichloroethylene) |
cancer |
| DDT (Dichlorodiphenyl-trichloroethane) |
cancer |
| o,p’-DDT |
developmental, female, male |
| p,p’-DDT |
developmental, female, male |
| DDVP (Dichlorvos) |
cancer |
| 2,4-DP (dichloroprop) Delisted January 25, 2002 [Click here for the basis for delisting] |
developmental |
| Demeclocycline hydrochloride (internal use) |
developmental |
| N,N’-Diacetylbenzidine |
cancer |
| 2,4-Diaminoanisole |
cancer |
| 2,4-Diaminoanisole sulfate |
cancer |
| 4,4′-Diaminodiphenyl ether (4,4′-Oxydianiline) |
cancer |
| 2,4-Diaminotoluene |
cancer |
| Diaminotoluene (mixed) |
cancer |
| Diazepam |
developmental |
| Diazoaminobenzene |
cancer |
| Diazoxide |
developmental |
| Dibenz[a,h]acridine |
cancer |
| Dibenz[a,j]acridine |
cancer |
| Dibenzanthracenes |
cancer |
| Dibenz[a,c]anthracene |
cancer |
| Dibenz[a,h]anthracene |
cancer |
| Dibenz[a,j]anthracene |
cancer |
| 7H-Dibenzo[c,g]carbazole |
cancer |
| Dibenzo[a,e]pyrene |
cancer |
| Dibenzo[a,h]pyrene |
cancer |
| Dibenzo[a,i]pyrene |
cancer |
| Dibenzo[a,l]pyrene |
cancer |
| Dibromoacetic acid |
cancer |
| Dibromoacetonitrile |
cancer |
| 1,2-Dibromo-3-chloropropane (DBCP) |
cancer |
| 1,2-Dibromo-3-chloropropane (DBCP) [Basis for listing changed effective November 22, 2013] |
male |
| 2,3-Dibromo-1-propanol |
cancer |
| Dichloroacetic acid |
cancer |
| Dichloroacetic acid |
developmental, male |
| p-Dichlorobenzene |
cancer |
| 3,3′-Dichlorobenzidine |
cancer |
| 3,3′-Dichlorobenzidine dihydrochloride |
cancer |
| 1,1-Dichloro-2,2-bis(p-chloropheny)ethylene (DDE) |
developmental, male |
| 1,4-Dichloro-2-butene |
cancer |
| 3,3′-Dichloro-4,4′-diamino-diphenyl ether |
cancer |
| 1,1-Dichloroethane |
cancer |
| Dichloromethane (Methylene chloride) |
cancer |
| Dichlorophene |
developmental |
| Dichlorphenamide |
developmental |
| 1,2-Dichloropropane |
cancer |
| 1,3-Dichloro-2-propanol (1,3-DCP) |
cancer |
| 1,3-Dichloropropene |
cancer |
| Diclofop-methyl |
cancer |
| Diclofop methyl |
developmental |
| Dicumarol |
developmental |
| Dieldrin |
cancer |
| Dienestrol Delisted January 4, 2013 [Click here for the basis for delisting] |
cancer |
| Diepoxybutane |
cancer |
| Diesel engine exhaust |
cancer |
| Diethanolamine |
cancer |
| Di(2-ethylhexyl)phthalate |
cancer |
| Di(2-ethylhexyl)phthalate |
developmental, male |
| Adultb |
|
| Infant boys, age 29 days to 24 monthsb |
|
| Neonatal infant boys, age 0 to 28 daysb |
|
| Adultb |
|
| Infant boys, age 29 days to 24 monthsb |
|
| Neonatal infant boys, age 0 to 28 daysb |
|
| 1,2-Diethylhydrazine |
cancer |
| Diethylstilbestrol (DES) |
cancer |
| Diethylstilbestrol (DES) |
developmental |
| Diethyl sulfate |
cancer |
| Diflunisal |
developmental, female |
| Diglycidyl ether Delisted April 4, 2014 [Click here for the basis for delisting] |
male |
| Diglycidyl resorcinol ether (DGRE) |
cancer |
| Dihydroergotamine mesylate |
developmental |
| Dihydrosafrole |
cancer |
| Diisononyl phthalate (DINP) |
cancer |
| Diisopropyl sulfate |
cancer |
| Di-isodecyl phthalate (DIDP) |
developmental |
| Diltiazem hydrochloride |
developmental |
| 3,3′-Dimethoxybenzidine (o-Dianisidine) |
cancer |
| 3,3′-Dimethoxybenzidine dihydrochloride |
cancer |
| 3,3′-Dimethoxybenzidine-based dyes metabolized to 3,3′-dimethoxybenzidine |
cancer |
| N,N-Dimethylacetamide [Click here for the basis for addition of male reproductive endpoint, effective December 20, 2013] |
developmental, male |
| 4-Dimethylaminoazobenzene |
cancer |
| trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2-furyl)vinyl]-1,3,4-oxadiazole |
cancer |
| 7,12-Dimethylbenz(a)anthracene |
cancer |
| 3,3′-Dimethylbenzidine (ortho-Tolidine) |
cancer |
| 3,3′-Dimethylbenzidine dihydrochloride |
cancer |
| 3,3′-Dimethylbenzidine-based dyes metabolized to 3,3′-dimethylbenzidine |
cancer |
| Dimethylcarbamoyl chloride |
cancer |
| 1,1-Dimethylhydrazine (UDMH) |
cancer |
| 1,2-Dimethylhydrazine |
cancer |
| 2,6-Dimethyl-N-nitrosomorpholine (DMNM) |
cancer |
| Dimethyl sulfate |
cancer |
| N,N-Dimethyl-p-toluidine |
cancer |
| Dimethylvinylchloride |
cancer |
| Di-n-butyl phthalate (DBP) |
developmental, female, male |
| Di-n-hexyl phthalate (DnHP) |
female, male |
| m-Dinitrobenzene |
male |
| o-Dinitrobenzene |
male |
| p-Dinitrobenzene |
male |
| 3,7-Dinitrofluoranthene |
cancer |
| 3,9-Dinitrofluoranthene |
cancer |
| 1,3-Dinitropyrene |
cancer |
| 1,6-Dinitropyrene |
cancer |
| 1,8-Dinitropyrene |
cancer |
| 2,4-Dinitrotoluene |
cancer |
| 2,4-Dinitrotoluene |
male |
| 2,6-Dinitrotoluene |
cancer |
| 2,6-Dinitrotoluene |
male |
| Dinitrotoluene (technical grade) |
female, male |
| Dinitrotoluene mixture, 2,4-/2,6- |
cancer |
| Dinocap |
developmental |
| Dinoseb |
developmental, male |
| Di-n-propyl isocinchomeronate (MGK Repellent 326) |
cancer |
| 1,4-Dioxane |
cancer |
| Diphenylhydantoin (Phenytoin) |
cancer |
| Diphenylhydantoin (Phenytoin) |
developmental |
| Diphenylhydantoin (Phenytoin), sodium salt |
cancer |
| Direct Black 38 (technical grade) |
cancer |
| Direct Blue 6 (technical grade) |
cancer |
| Direct Brown 95 (technical grade) |
cancer |
| Disodium cyanodithioimidocarbonate |
developmental |
| Disperse Blue 1 |
cancer |
| Diuron |
cancer |
| Doxorubicin hydrochloride (Adriamycin) |
cancer |
| Doxorubicin hydrochloride (Adriamycin) |
developmental, male |
| Doxycycline (internal use) |
developmental |
| Doxycycline calcium (internal use) |
developmental |
| Doxycycline hyclate (internal use) |
developmental |
| Doxycycline monohydrate (internal use) |
developmental |
|
|
| Emissions from combustion of coal |
cancer |
| Emissions from high-temperature unrefined rapeseed oil |
cancer |
| Endrin |
developmental |
| Environmental tobacco smoke (ETS) |
developmental |
| Epichlorohydrin |
cancer |
| Epichlorohydrin |
male |
| Epoxiconazole |
cancer |
| Ergotamine tartrate |
developmental |
| Erionite |
cancer |
| Estradiol 17B |
cancer |
| Estragole |
cancer |
| Estrogens, steroidal |
cancer |
| Estrogen-progestogen (combined) used as menopausal therapy |
cancer |
| Estrone |
cancer |
| Estropipate |
cancer, developmental |
| Ethanol in alcoholic beverages |
cancer |
| Ethinylestradiol |
cancer |
| Ethionamide |
developmental |
| Ethoprop |
cancer |
| Ethyl acrylate |
cancer |
| Ethyl alcohol in alcoholic beverages |
developmental |
| Ethylbenzene |
cancer |
| Ethyl-tert-butyl ether Delisted December 13, 2013 [Clik here for the basis for delisting] |
male |
| Ethyl dipropylthiocarbamate |
developmental |
| Ethyl-4,4′-dichlorobenzilate |
cancer |
| Ethylene dibromide |
cancer |
| Ethylene dibromide |
developmental, male |
| Ethylene dichloride (1,2-Dichloroethane) |
cancer |
| Ethylene glycol monoethyl ether |
developmental, male |
| Ethylene glycol monoethyl ether acetate |
developmental, male |
| Ethylene glycol monomethyl ether |
developmental, male |
| Ethylene glycol monomethyl ether acetate |
developmental, male |
| Ethyleneimine |
cancer |
| Ethylene oxide |
cancer |
| Ethylene oxide [Basis for listing changed effective November 22, 2013] |
female |
| Ethylene oxide [Basis for listing changed effective November 22, 2013] |
developmental, male |
| Ethylene thiourea |
cancer |
| Ethylene thiourea |
developmental |
| 2-Ethylhexanoic acid Delisted December 13, 2013 [Click here for the basis for delisting] |
developmental |
| Ethyl methanesulfonate |
cancer |
| Etodolac |
developmental, female |
| Etoposide |
cancer |
| Etoposide |
developmental |
| Etoposide in combination with cisplatin and bleomycin |
cancer |
| Etretinate |
developmental |
|
|
| Fenoxaprop ethyl |
developmental |
| Fenoxycarb |
cancer |
| Filgrastim |
developmental |
| Fluazifop butyl |
developmental |
| Flunisolide |
developmental, female |
| Fluorouracil |
developmental |
| Fluoxymesterone |
developmental |
| Flurazepam hydrochloride |
developmental |
| Flurbiprofen |
developmental, female |
| Flutamide |
developmental |
| Fluticasone propionate |
developmental |
| Fluvalinate |
developmental |
| Folpet |
cancer |
| Formaldehyde (gas) |
cancer |
| 2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole |
cancer |
| Fumonisin B1 |
cancer |
| Furan |
cancer |
| Furazolidone |
cancer |
| Furmecyclox |
cancer |
| Fusarin C |
cancer |
|
|
| Gallium arsenide |
cancer |
| Ganciclovir |
cancer, developmental, male |
| Ganciclovir sodium |
developmental, male |
| Gasoline engine exhaust (condensates/extracts) |
cancer |
| Gemfibrozil |
cancer |
| Gemfibrozil |
female, male |
| Glass wool fibers (inhalable and biopersistent) |
cancer |
| Glu-P-1 (2-Amino-6-methyldipyrido[1,2- a:3′,2′-d]imidazole) |
cancer |
| Glu-P-2 (2-Aminodipyrido[1,2-a:3′,2′-d]imidazole) |
cancer |
| Glycidaldehyde |
cancer |
| Glycidol |
cancer |
| Goserelin acetate |
developmental, female, male |
| Griseofulvin |
cancer |
| Gyromitrin (Acetaldehyde methylformylhydrazone) |
cancer |
|
|
| Halazepam |
developmental |
| Halobetasol propionate |
developmental |
| Haloperidol |
developmental, female |
| Halothane |
developmental |
| HC Blue 1 |
cancer |
| Heptachlor |
cancer |
| Heptachlor |
developmental |
| Heptachlor epoxide |
cancer |
| Herbal remedies containing plant species of the genus Aristolochia |
cancer |
| Hexachlorobenzene |
cancer |
| Hexachlorobenzene |
developmental |
| Hexachlorobutadiene |
cancer |
| Hexachlorocyclohexane (technical grade) |
cancer |
| Hexachlorocyclohexane (alpha isomer) |
|
| Hexachlorocyclohexane (beta isomer) |
|
| Hexachlorocyclohexane (gamma isomer) |
|
| Hexachlorodibenzodioxin |
cancer |
| Hexachloroethane |
cancer |
| 2,4-Hexadienal (89% trans, trans isomer; 11% cis, trans isomer) |
cancer |
| Hexafluoroacetone [Basis for listing changed effective June 6, 2014] |
developmental, male |
| Hexamethylphosphoramide |
cancer |
| Hexamethylphosphoramide |
male |
| Histrelin acetate |
developmental |
| Hydramethylnon |
developmental, male |
| Hydrazine |
cancer |
| Hydrazine sulfate |
cancer |
| Hydrazobenzene (1,2-Diphenylhydrazine) |
cancer |
| Hydrogen cyanide (HCN) and cyanide salts (CN salts) |
male |
| Cyanide salts that readily dissociate in solution (expressed as cyanide)f |
|
| Hydrogen cyanidef |
|
| Sodium cyanidef |
|
| Potassium cyanidef |
|
| 1-Hydroxyanthraquinone |
cancer |
| Hydroxyurea |
developmental |
|
|
| Idarubicin hydrochloride |
developmental, male |
| Ifosfamide |
developmental |
| Iodine-131 |
developmental |
| Imazalil |
cancer |
| Indeno [1,2,3-cd]pyrene |
cancer |
| Indium phosphide |
cancer |
| IQ (2-Amino-3-methylimidazo[4,5-f] quinoline) |
cancer |
| Iprodione |
cancer |
| Iprovalicarb |
cancer |
| Iron dextran complex |
cancer |
| Isobutyl nitrite |
cancer |
| Isoprene |
cancer |
| Isopyrazam |
cancer |
| Isosafrole Delisted December 8, 2006 [Click here for the basis for delisting] |
cancer |
| Isotretinoin |
developmental |
| Isoxaflutole |
cancer |
| |
|
| Kresoxim-methyl |
cancer |
| |
|
| Lactofen |
cancer |
| Lasiocarpine |
cancer |
| Lead [Basis for listing changed effective November 22, 2013] |
developmental, female, male |
| Lead and lead compounds |
cancer |
| Lead |
|
| Lead acetate |
cancer |
| Lead phosphate |
cancer |
| Lead subacetate |
cancer |
| Leather dust |
cancer |
| Leuprolide acetate |
developmental, female, male |
| Levodopa |
developmental |
| Levonorgestrel implants |
female |
| Lindane and other hexachlorocyclohexane isomers |
cancer |
| Linuron |
developmental |
| Lithium carbonate |
developmental |
| Lithium citrate |
developmental |
| Lorazepam |
developmental |
| Lovastatin |
developmental |
| Lynestrenol |
cancer |
| |
|
| Malonaldehyde, sodium salt |
cancer |
| Mancozeb |
cancer |
| Maneb |
cancer |
| Marijuana smoke |
cancer |
| Me-A-alpha-C (2-Amino-3-methyl-9H-pyrido[2,3-b]indole) |
cancer |
| Mebendazole |
developmental |
| Medroxyprogesterone acetate |
cancer |
| Medroxyprogesterone acetate |
developmental |
| Megestrol acetate |
cancer |
| Megestrol acetate |
developmental |
| MeIQ (2-Amino-3,4-dimethylimidazo[4,5-f]quinoline) |
cancer |
| MeIQx (2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline) |
cancer |
| Melphalan |
cancer |
| Melphalan |
developmental |
| Menotropins |
developmental |
| Mepanipyrim |
cancer |
| Meprobamate |
developmental |
| Mercaptopurine |
developmental |
| Mercury and mercury compounds |
developmental |
| Merphalan |
cancer |
| Mestranol |
cancer |
| Metam potassium |
cancer |
| Methacycline hydrochloride |
developmental |
| Metham sodium |
cancer |
| Metham sodium |
developmental |
| Methanol |
developmental |
| Methazole |
developmental |
| Methimazole |
developmental |
| Methotrexate |
developmental |
| Methotrexate sodium |
developmental |
| 5-Methoxypsoralen with ultraviolet A therapy |
cancer |
| 8-Methoxypsoralen with ultraviolet A therapy |
cancer |
| 2-Methylaziridine (Propyleneimine) |
cancer |
| Methylazoxymethanol |
cancer |
| Methylazoxymethanol acetate |
cancer |
| Methyl bromide, as a structural fumigant |
developmental |
| Methyl n-butyl ketone |
male |
| Methyl carbamate |
cancer |
| Methyl chloride |
developmental |
| Methyl chloride [Basis for listing changed effective March 7, 2014] |
male |
| 3-Methylcholanthrene |
cancer |
| 5-Methylchrysene |
cancer |
| 4,4′-Methylene bis(2-chloroaniline) |
cancer |
| 4,4′-Methylene bis(N,N-dimethyl)benzenamine |
cancer |
| 4,4′-Methylene bis(2-methylaniline) |
cancer |
| 4,4′-Methylenedianiline |
cancer |
| 4,4′-Methylenedianiline dihydrochloride |
cancer |
| Methyleugenol |
cancer |
| Methylhydrazine and its salts |
cancer |
| Methylhydrazine |
|
| Methylhydrazine sulfate |
|
| 2-Methylimidazole |
cancer |
| 4-Methylimidazole |
cancer |
| Methyl iodide |
cancer |
| Methyl isobutyl ketone |
cancer |
| Methyl isobutyl ketone (MIBK) |
developmental |
| Methyl isocyanate (MIC) |
developmental, female |
| Methyl isopropyl ketone Delisted April 4, 2014 [Click for the basis for delisting] |
developmental |
| Methyl mercury |
developmental |
| Methylmercury compounds |
cancer |
| Methyl methanesulfonate |
cancer |
| 2-Methyl-1-nitroanthraquinone (of uncertain purity) |
cancer |
| N-Methyl-N’-nitro-N-nitrosoguanidine |
cancer |
| N-Methylolacrylamide |
cancer |
| N-Methylpyrrolidone |
developmental |
| α-Methyl styrene (alpha-Methylstyrene) |
cancer |
| α-Methyl styrene Delisted April 4, 2014 [Click for the basis for delisting] |
female |
| Methyltestosterone |
developmental |
| Methylthiouracil |
cancer |
| Metiram |
cancer |
| Metiram |
developmental |
| Metronidazole |
cancer |
| Michler’s ketone |
cancer |
| Midazolam hydrochloride |
developmental |
| Minocycline hydrochloride (internal use) |
developmental |
| Mirex |
cancer |
| Misoprostol |
developmental |
| Mitomycin C |
cancer |
| Mitoxantrone hydrochloride |
cancer |
| Mitoxantrone hydrochloride |
developmental |
| Molinate |
developmental, female, male |
| MON 4660 (dichloroacetyl-1-oxa-4-azaspiro(4,5)-decane |
cancer |
| MON 13900 (furilazole) |
cancer |
| 3-Monochloropropane-1,2-diol (3-MCDP) |
cancer |
| Monocrotaline |
cancer |
| MOPP (vincristine-prednisone-nitrogen mustard-procarbazine mixture) |
cancer |
| 5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)-amino]-2-oxazolidinone |
cancer |
| Mustard Gas |
cancer |
| MX (3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone) |
cancer |
| Myclobutanil |
developmental, male |
|
|
| Nabam |
developmental |
| Nafarelin acetate |
developmental |
| Nafenopin |
cancer |
| Nalidixic acid |
cancer |
| Naphthalene |
cancer |
| 1-Naphthylamine |
cancer |
| 2-Naphthylamine |
cancer |
| Neomycin sulfate (internal use) |
developmental |
| Netilmicin sulfate |
developmental |
| Nickel (Metallic) |
cancer |
| Nickel acetate |
cancer |
| Nickel carbonate |
cancer |
| Nickel carbonyl |
cancer |
| Nickel carbonyl |
developmental |
| Nickel compounds |
cancer |
| Nickel hydroxide |
cancer |
| Nickelocene |
cancer |
| Nickel oxide |
cancer |
| Nickel refinery dust from the pyrometallurgical process |
cancer |
| Nickel subsulfide |
cancer |
| Nicotine |
developmental |
| Nifedipine |
developmental, female, male |
| Nimodipine |
developmental |
| Niridazole |
cancer |
| Nitrapyrin |
cancer |
| Nitrapyrin |
developmental |
| Nitrilotriacetic acid |
cancer |
| Nitrilotriacetic acid, trisodium salt monohydrate |
cancer |
| 5-Nitroacenaphthene |
cancer |
| 5-Nitro-o-anisidine Delisted December 8, 2006 [Click here for the basis for delisting] |
cancer |
| o-Nitroanisole |
cancer |
| Nitrobenzene |
cancer |
| Nitrobenzene |
male |
| 4-Nitrobiphenyl |
cancer |
| 6-Nitrochrysene |
cancer |
| Nitrofen (technical grade) |
cancer |
| 2-Nitrofluorene |
cancer |
| Nitrofurantoin |
male |
| Nitrofurazone |
cancer |
| 1-[(5-Nitrofurfurylidene)-amino]-2-imidazolidinone |
cancer |
| N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide |
cancer |
| Nitrogen mustard (Mechlorethamine) |
cancer |
| Nitrogen mustard (Mechlorethamine) |
developmental |
| Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) |
cancer |
| Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) |
developmental |
| Nitrogen mustard N-oxide |
cancer |
| Nitrogen mustard N-oxide hydrochloride |
cancer |
| Nitromethane |
cancer |
| 2-Nitropropane |
cancer |
| 1-Nitropyrene |
cancer |
| 4-Nitropyrene |
cancer |
| N-Nitrosodiethanolamine |
cancer |
| N-Nitrosodiethylamine |
cancer |
| N-Nitrosodimethylamine |
cancer |
| N-Nitrosodi-n-butylamine |
cancer |
| N-Nitrosodi-n-propylamine |
cancer |
| p-Nitrosodiphenylamine |
cancer |
| N-Nitrosodiphenylamine |
cancer |
| 3-(N-Nitrosomethylamino) propionitrile |
cancer |
| 4-(N-Nitrosomethylamino)-1-(3-pyridyl)1-butanone |
cancer |
| N-Nitrosomethyl-n-butylamine |
cancer |
| N-Nitrosomethyl-n-decylamine |
cancer |
| N-Nitrosomethyl-n-dodecylamine |
cancer |
| N-Nitrosomethylethylamine |
cancer |
| N-Nitrosomethyl-n-heptylamine |
cancer |
| N-Nitrosomethyl-n-hexylamine |
cancer |
| N-Nitrosomethyl-n-nonylamine |
cancer |
| N-Nitrosomethyl-n-octylamine |
cancer |
| N-Nitrosomethyl-n-pentylamine |
cancer |
| N-Nitrosomethyl-n-propylamine |
cancer |
| N-Nitrosomethyl-n-tetradecylamine |
cancer |
| N-Nitrosomethyl-n-undecylamine |
cancer |
| N-Nitrosomethylvinylamine |
cancer |
| N-Nitrosomorpholine |
cancer |
| N-Nitroso-N-ethylurea |
cancer |
| N-Nitroso-N-methylurea |
cancer |
| N-Nitroso-N-methylurethane |
cancer |
| N-Nitrosonornicotine |
cancer |
| N-Nitrosopiperidine |
cancer |
| N-Nitrosopyrrolidine |
cancer |
| N-Nitrososarcosine |
cancer |
| o-Nitrotoluene |
cancer |
| Nitrous oxide [Basis for listing changed effective November 8, 2013] |
developmental, female |
| Norethisterone (Norethindrone) |
cancer |
| Norethisterone (Norethindrone) |
developmental |
| Norethisterone acetate (Norethindrone acetate) |
developmental |
| Norethisterone (Norethindrone) /Ethinyl estradiol |
developmental |
| Norethisterone (Norethindrone) /Mestranol |
developmental |
| Norethynodrel |
cancer |
| Norgestrel |
developmental |
|
|
| Ochratoxin A |
cancer |
| Oil Orange SS |
cancer |
| Oral contraceptives, combined |
cancer |
| Oral contraceptives, sequential |
cancer |
| Oryzalin |
cancer |
| Oxadiazon |
cancer |
| Oxadiazon |
developmental |
| Oxazepam |
cancer |
| Oxazepam |
developmental |
| p,p’-Oxybis(benzenesulfonyl hydrazide) Delisted December 13, 2013 [Click here for the basis for delisting] |
developmental |
| Oxydemeton methyl |
female, male |
| Oxymetholone |
cancer |
| Oxymetholone |
developmental |
| Oxytetracycline (internal use) |
developmental |
| Oxytetracycline hydrochloride (internal use) |
developmental |
| Oxythioquinox (Chinomethionat) |
cancer |
| Oxythioquinox (Chinomethionat) |
developmental |
|
|
| Paclitaxel |
developmental, female, male |
| Palygorskite fibers (> 5mm in length) |
cancer |
| Panfuran S |
cancer |
| Paramethadione |
developmental |
| Penicillamine |
developmental |
| Pentachlorophenol |
cancer |
| Pentobarbital sodium |
developmental |
| Pentosan polysulfate sodium |
cancer |
| Pentostatin |
developmental |
| Phenacemide |
developmental |
| Phenacetin |
cancer |
| Phenazopyridine |
cancer |
| Phenazopyridine hydrochloride |
cancer |
| Phenesterin |
cancer |
| Phenobarbital |
cancer |
| Phenolphthalein |
cancer |
| Phenoxybenzamine |
cancer |
| Phenoxybenzamine hydrochloride |
cancer |
| Phenprocoumon |
developmental |
| o-Phenylenediamine and its salts |
cancer |
| o-Phenylenediamine |
|
| o-Phenylenediamine dihydochloride |
|
| Phenyl glycidyl ether |
cancer |
| Phenyl glycidyl ether |
male |
| Delisted April 4, 2014 [Click here |
|
| for the basis for delisting] |
|
| Phenylhydrazine and its salts |
cancer |
| Phenylhydrazine |
|
| Phenylhydrazine hydrochloride |
|
| o-Phenylphenate, sodium |
cancer |
| o-Phenylphenol |
cancer |
| Phenylphosphine [Basis for listing changed effective June 6, 2014] |
developmental male |
| PhiP(2-Amino-1-methyl-6-phenylimidazol[4,5-b]pyridine) |
cancer |
| Pimozide |
developmental, female |
| Pioglitazone |
cancer |
| Pipobroman |
developmental |
| Pirimicarb |
cancer |
| Plicamycin |
developmental |
| Polybrominated biphenyls |
cancer |
| Polybrominated biphenyls |
developmental |
| Polychlorinated biphenyls |
cancer |
| Polychlorinated biphenyls |
developmental |
| Polychlorinated biphenyls (containing 60 or more percent percent chlorine by molecular weight) |
cancer |
| Polychlorinated dibenzo-p-dioxins |
cancer |
| Polychlorinated dibenzofurans |
cancer |
| Polygeenan |
cancer |
| Ponceau MX |
cancer |
| Ponceau 3R |
cancer |
| Potassium bromate |
cancer |
| Potassium dimethyldithiocarbamate |
developmental |
| Pravastatin sodium |
developmental |
| Prednisolone sodium phosphate |
developmental |
| Primidone |
cancer |
| Procarbazine |
cancer |
| Procarbazine hydrochloride |
cancer |
| Procarbazine hydrochloride |
developmental |
| Procymidone |
cancer |
| Progesterone |
cancer |
| Pronamide |
cancer |
| Propachlor |
cancer |
| 1,3-Propane sultone |
cancer |
| Propargite |
cancer |
| Propargite |
developmental |
| beta-Propiolactone |
cancer |
| Propoxur |
cancer |
| Propylene glycol mono-t-butyl ether |
cancer |
| Propylene oxide |
cancer |
| Propylthiouracil |
cancer |
| Propylthiouracil |
developmental |
| Pulegone |
cancer |
| Pymetrozine |
cancer |
| Pyridine |
cancer |
| Pyrimethamine |
developmental |
|
|
| Quazepam |
developmental |
| Quinoline and its strong acid salts |
cancer |
| Quizalofop-ethyl |
male |
|
|
| Radionuclides |
cancer |
| Reserpine |
cancer |
| Residual (heavy) fuel oils |
cancer |
| Resmethrin |
cancer |
| Resmethrin |
developmental |
| Retinol/retinyl esters, when in daily dosages in excess of 10,000 IU, or 3,000 retinol equivalents. (NOTE: Retinol/retinyl esters are required and essential for maintenance of normal reproductive function. The recommended daily level during pregnancy is 8,000 IU.) |
developmental |
| Ribavirin |
developmental |
| Ribavirin |
male |
| Riddelliine |
cancer |
| Rifampin |
developmental, female |
|
|
| Saccharin Delisted April 6, 2001 [Click here for the basis for delisting] |
cancer |
| Saccharin, sodium Delisted January 17, 2003 [Click here for the basis for delisting] |
cancer |
| Safrole |
cancer |
| Salted fish, Chinese-style |
cancer |
| Secobarbital sodium |
developmental |
| Selenium sulfide |
cancer |
| Sermorelin acetate |
developmental |
| Shale-oils |
cancer |
| Silica, crystalline (airborne particles of respirable size) |
cancer |
| Sodium dimethyldithiocarbamate |
developmental |
| Sodium fluoroacetate |
male |
| Soots, tars, and mineral oils (untreated and mildly treated oils and used engine oils) |
cancer |
| Spirodiclofen |
cancer |
| Spironolactone |
cancer |
| Stanozolol |
cancer |
| Sterigmatocystin |
cancer |
| Streptomycin sulfate |
developmental |
| Streptozocin (streptozotocin) |
developmental, female, male |
| Streptozotocin (streptozocin) |
cancer |
| Strong inorganic acid mists containing sulfuric acid |
cancer |
| Styrene oxide |
cancer |
| Sulfallate |
cancer |
| Sulfasalazine (salicylazosulfapyridine) |
cancer |
| Sulfasalazine (salicylazosulfapyridine) |
male |
| Sulfur dioxidee |
developmental |
| Sulindac |
developmental, female |
|
|
| Talc containing asbestiform fibers |
cancer |
| Tamoxifen and its salts |
cancer |
| Tamoxifen citrate |
developmental |
| Temazepam |
developmental |
| Teniposide |
developmental |
| Terbacil |
developmental |
| Terrazole |
cancer |
| Testosterone and its esters |
cancer |
| Testosterone cypionate |
developmental |
| Testosterone enanthate |
developmental |
| 3,3′,4,4′-Tetrachloroazobenzene |
cancer |
| 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) |
cancer |
| 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) |
developmental |
| 1,1,1,2-Tetrachloroethane |
cancer |
| 1,1,2,2-Tetrachloroethane |
cancer |
| Tetrachloroethylene (Perchloroethylene) |
cancer |
| p-a,a,a-Tetrachlorotoluene |
cancer |
| Tetracycline (internal use) |
developmental |
| Tetracyclines (internal use) |
developmental |
| Tetracycline hydrochloride (internal use) |
developmental |
| Tetrafluoroethylene |
cancer |
| Tetranitromethane |
cancer |
| Thalidomide |
developmental |
| Thioacetamide |
cancer |
| 4,4′-Thiodianiline |
cancer |
| Thiodicarb |
cancer |
| Thioguanine |
developmental |
| Thiophanate methyl |
female, male |
| Thiouracil |
cancer |
| Thiourea |
cancer |
| Thorium dioxide |
cancer |
| Titanium dioxide (airborne, unbound particles of respirable size) |
cancer |
| Tobacco, oral use of smokeless products |
cancer |
| Tobacco smoke |
cancer |
| Tobacco smoke (primary) |
developmental, female, male |
| Tobramycin sulfate |
developmental |
| Toluene |
developmental |
| Toluene [Click here for the basis for the removal of female reproductive endpoint effective March 7, 2014] |
female |
| Toluene diisocyanate |
cancer |
| o-Toluidine |
cancer |
| o-Toluidine hydrochloride |
cancer |
| para-Toluidine Delisted October 29, 1999 [Click here for the basis for delisting] |
cancer |
| Toxaphene (Polychlorinated camphenes) |
cancer |
| Toxins derived from Fusarium moniliforme (Fusarium verticillioides) |
cancer |
| Treosulfan |
cancer |
| Triadimefon |
developmental, female, male |
| Triamterene |
cancer |
| Triazolam |
developmental |
| S,S,S-Tributyl phosphorotrithioate (Tribufos, DEF) |
cancer |
| Tributyltin methacrylate |
developmental |
| Trichlormethine (Trimustine hydrochloride) |
cancer |
| Trichloroacetic acid |
cancer |
| Trichloroethylene |
cancer |
| Trichloroethylene |
developmental, male |
| 2,4,6-Trichlorophenol |
cancer |
| 1,2,3-Trichloropropane |
cancer |
| Trientine hydrochloride |
developmental |
| Triforine |
developmental |
| 1,3,5-Triglycidyl-s-triazinetrione Delisted December 13, 2013 [Click here for the basis for delisting] |
male |
| Trilostane |
developmental |
| Trimethadione |
developmental |
| 2,4,5-Trimethylaniline and its strong acid salts |
cancer |
| Trimethyl phosphate |
cancer |
| Trimetrexate glucuronate |
developmental |
| 2,4.6-Trinitrotoluene (TNT) |
cancer |
| Triphenyltin hydroxide |
cancer |
| Triphenyltin hydroxide |
developmental |
| Tris(aziridinyl)-p-benzoquinone (Triaziquone) Delisted December 8, 2006 [Click here for the basis for delisting] |
cancer |
| Tris(1-aziridinyl)phosphine sulfide (Thiotepa) |
cancer |
| Tris(2-chloroethyl) phosphate |
cancer |
| Tris(2,3-dibromopropyl)phosphate |
cancer |
| Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) |
cancer |
| Trp-P-1 (Tryptophan-P-1) |
cancer |
| Trp-P-2 (Tryptophan-P-2) |
cancer |
| Trypan blue (commercial grade) |
cancer |
|
|
| Unleaded gasoline (wholly vaporized) |
cancer |
| Uracil mustard |
cancer |
| Uracil mustard |
developmental, female, male |
| Urethane (Ethyl carbamate) |
cancer |
| Urethane (Ethyl carbamate) |
developmental |
| Urofollitropin |
developmental |
|
|
| Valproate (Valproic acid) |
developmental |
| Vanadium pentoxide (orthorhombic crystalline form) |
cancer |
| Vinblastine sulfate |
developmental |
| Vinclozolin |
cancer |
| Vinclozolin |
developmental |
| Vincristine sulfate |
developmental |
| Vinyl bromide |
cancer |
| Vinyl chloride |
cancer |
| 4-Vinylcyclohexene |
cancer |
| 4-Vinylcyclohexene [Click here for the basis for the removal of male reproductive endpoint, effective December 20, 2013 ] |
female, male |
| 4-Vinyl-1-cyclohexene diepoxide (Vinyl cyclohexenedioxide) |
cancer |
| Vinyl cyclohexene dioxide (4-Vinyl-1-cyclohexene diepoxide) [Click here for the basis for the removal of male reproductive endpoint, effective December 20, 2013] |
female, male |
| Vinyl fluoride |
cancer |
| Vinyl trichloride (1,1,2-Trichloroethane) |
cancer |
| Warfarin |
developmental |
| Wood dust |
cancer |
|
|
| 2,6-Xylidine (2,6-Dimethylaniline) |
cancer |
| Zalcitabine |
cancer |
| Zidovudine (AZT) |
cancer |
| Zileuton |
cancer, developmental, female |
| Zineb Delisted October 29, 1999 [Click here for the basis for delisting] |
cancer |
