Proposition 65 Toxic Chemical List, (updated January, 2015)


The Safe Drinking Water and Toxic Enforcement Act of 1986 requires that the Governor revise and republish at least once per year the list of chemicals known to the State to cause cancer or reproductive toxicity. For easy reference, chemicals which are newly added are shown in underline. Chemicals or endpoints shown in strikeout were placed on the Proposition 65 list on the date noted, and have subsequently been removed.A hyperlink is provided for the basis for removing the chemical.
               See the list in its entirety at
A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole) cancer
Acetaldehyde cancer
Acetamide cancer
Acetazolamide developmental
Acetochlor cancer
Acetohydroxamic acid developmental
2-Acetylaminofluorene cancer
Acifluorfen sodium cancer
Acrylamide cancer
Acrylamide developmental, male
Acrylonitrile cancer
Actinomycin D [Basis for listing changed effective February 22, 2013] cancer
Actinomycin D developmental
AF-2;[2-(2-furyl)-3-(5-nitro-2-furyl)]acrylamide cancer
Aflatoxins cancer
Alachlor cancer
Alcoholic beverages, when associated with alcohol abuse cancer
Aldrin cancer
All-trans retinoic acid developmental
Allyl chloride Delisted October 29, 1999 [Click here for the basis for delisting] cancer
Alprazolam developmental
Altretamine developmental, male
Amantadine hydrochloride developmental
Amikacin sulfate developmental
2-Aminoanthraquinone cancer
p-Aminoazobenzene cancer
o-Aminoazotoluene cancer
4-Aminobiphenyl (4-aminodiphenyl) cancer
1-Amino-2,4-dibromoanthraquinone cancer
3-Amino-9-ethylcarbazole hydrochloride cancer
2-Aminofluorene cancer
Aminoglutethimide developmental
Aminoglycosides developmental
1-Amino-2-methylanthraquinone cancer
2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole cancer
4-Amino-2-nitrophenol cancer
Aminopterin developmental, female
Amiodarone hydrochloride developmental, female, male
Amitraz developmental
Amitrole cancer
Amoxapine developmental
Amsacrine cancer
tert-Amyl methyl ether Delisted December 13, 2013 [Click here for the basis for delisting] developmental
Anabolic steroids female, male
Analgesic mixtures containing Phenacetin cancer
Androstenedione cancer
Angiotensin converting enzyme (ACE) inhibitors developmental
Aniline cancer
Aniline hydrochloride cancer
o-Anisidine cancer
o-Anisidine hydrochloride cancer
Anisindione developmental
Anthraquinone cancer
Antimony oxide (Antimony trioxide) cancer
Aramite cancer
Areca nut cancer
Aristolochic acids cancer
Arsenic (inorganic arsenic compounds) cancer
Arsenic (inorganic oxides) developmental
Asbestos cancer
Aspirin (NOTE: It is especially important not to use aspirin during the last three months of pregnancy,   unless specifically directed to do so by a physician because it may cause problems in the unborn child or complications during delivery.) developmental, female
Atenolol developmental
Auramine cancer
Auranofin developmental
Avermectin B1 (Abamectin) developmental
Azacitidine cancer
Azaserine cancer
Azathioprine cancer
Azathioprine developmental
Azobenzene cancer
Barbiturates developmental
Beclomethasone dipropionate developmental
Benomyl developmental, male
Benthiavalicarb-isopropyl cancer
Benz[a]anthracene cancer
Benzene cancer
Benzene developmental, male
Benzidine [and its salts] cancer
Benzidine-based dyes cancer
Benzodiazepines developmental
Benzo[b]fluoranthene cancer
Benzo[j]fluoranthene cancer
Benzo[k]fluoranthene cancer
Benzofuran cancer
Benzophenone cancer
Benzo[a]pyrene cancer
Benzotrichloride cancer
Benzphetamine hydrochloride developmental
Benzyl chloride cancer
Benzyl violet 4B cancer
Beryllium and beryllium compounds cancer
   Beryllium oxide
   Beryllium sulfate
Betel quid with tobacco cancer
Betel quid without tobacco cancer
2,2-Bis(bromomethyl)-1,3-propanediol cancer
Bis(2-chloroethyl)ether cancer
N,N-Bis(2-chloroethyl)-2-naphthylamine (Chlornapazine) cancer
Bischloroethyl nitrosourea (BCNU) (Carmustine) cancer
Bischloroethyl nitrosourea (BCNU) (Carmustine) developmental
Bis(chloromethyl)ether cancer
Bis(2-chloro-1-methylethyl)ether, technical grade cancer
Bisphenol A (BPA) Delisted April 19, 2013 [Click here for the basis for delisting] developmental
Bitumens, extracts of steam-refined and air refined cancer
Bracken fern cancer
Bromacil lithium salt developmental
Bromacil lithium salt male
Bromate cancer
Bromochloroacetic acid cancer
Bromodichloromethane cancer
Bromoethane cancer
Bromoform cancer
1-Bromopropane (1-BP) developmental, female, male
2-Bromopropane (2-BP) female, male
Bromoxynil developmental
Bromoxynil octanoate developmental
Butabarbital sodium developmental
1,3-Butadiene cancer
1,3-Butadiene developmental, female, male
1,4-Butanediol dimethanesulfonate (Busulfan) cancer
1,4-Butanediol dimethanesulfonate (Busulfan) developmental
Butylated hydroxyanisole cancer
Butyl benzyl phthalate (BBP)d developmental
n-Butyl glycidyl ether Delisted April 4, 2014 [Click here for the basis for delisting] male
beta-Butyrolactone cancer
Cacodylic acid cancer
Cadmium developmental, male
Cadmium and cadmium compounds cancer
Caffeic acid cancer
Captafol cancer
Captan cancer
Carbamazepine developmental
Carbaryl cancer
Carbaryl [Basis for listing changed effective December 27, 2013] developmental, female, male
Carbazole cancer
Carbon black (airborne, unbound particles of respirable size) cancer
Carbon disulfide developmental, female, male
Carbon monoxide developmental
Carbon tetrachloride cancer
Carbon-black extracts cancer
Carboplatin developmental
N-Carboxymethyl-N-nitrosourea cancer
Catechol cancer
Ceramic fibers (airborne particles of respirable size) cancer
Certain combined chemotherapy for lymphomas cancer
Chenodiol developmental
Chloral cancer
Chloral hydrate cancer
Chlorambucil cancer
Chlorambucil developmental
Chloramphenicol Delisted January 4, 2013 [Click here for the basis for delisting] cancer
Chloramphenicol sodium succinate cancer
Chlorcyclizine hydrochloride developmental
Chlordane cancer
Chlordecone (Kepone) cancer
Chlordecone (Kepone) developmental
Chlordiazepoxide developmental
Chlordiazepoxide hydrochloride developmental
Chlordimeform cancer
Chlorendic acid cancer
Chlorinated paraffins (Average chain length, C12;approximately 60 percent chlorine by weight) cancer
p-Chloroaniline cancer
p-Chloroaniline hydrochloride cancer
Chlorodibromomethane Delisted October 29, 1999 [Click here for the basis for delisting] cancer
Chloroethane (Ethyl chloride) cancer
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) cancer
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) developmental
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (Methyl-CCNU) cancer
Chloroform cancer
Chloroform developmental
Chloromethyl methyl ether (technical grade) cancer
3-Chloro-2-methylpropene cancer
1-Chloro-4-nitrobenzene cancer
4-Chloro-o-phenylenediamine cancer
Chloroprene cancer
2-Chloropropionic acid [Basis for listing changed effective December 20, 2013] male
Chlorothalonil cancer
p-Chloro-o-toluidine cancer
p-Chloro-o-toluidine, strong acid salts of cancer
   p-Chloro-o-toluidine, hydrochloride
5-Chloro-o-toluidine and its strong acid salts cancer
Chlorotrianisene cancer
Chlorozotocin cancer
Chlorsulfuron Delisted June 6, 2014 [Click here for the basis for delisting] developmental, female, male
Chromium (hexavalent compounds) cancer
Chromium (hexavalent compounds) developmental, female, male
Chrysene cancer
C.I. Acid Red 114 cancer
C.I. Basic Red 9 monohydrochloride cancer
C.I. Direct Blue 15 cancer
C.I. Direct Blue 218 cancer
C.I. Disperse Yellow 3 cancer
C.I. Solvent Yellow 14 cancer
Ciclosporin (Cyclosporin A; Cyclosporine) cancer
Cidofovir cancer, developmental, female, male
Cinnamyl anthranilate cancer
Cisplatin cancer
Citrus Red No. 2 cancer
Cladribine developmental
Clarithromycin developmental
Clobetasol propionate developmental, female
Clofibrate cancer
Clomiphene citrate cancer
Clomiphene citrate developmental
Clorazepate dipotassium developmental
Cobalt metal powder cancer
Cobalt [II] oxide cancer
Cobalt sulfate cancer
Cobalt sulfate heptahydrate cancer
Cocaine developmental, female
Coconut oil diethanolamine condensate (cocamide diethanolamine) cancer
Codeine phosphate developmental
Coke oven emissions cancer
Colchicine developmental, male
Conjugated estrogens cancer
Conjugated estrogens developmental
Creosotes cancer
p-Cresidine cancer
Cumene cancer
Cupferron cancer
Cyanazine developmental
Cycasin cancer
Cycloate developmental
Cyclohexanol Delisted January 25, 2002 [Click here for the basis for delisting] male
Cycloheximide developmental
Cyclopenta[cd]pyrene cancer
Cyclophosphamide (anhydrous) cancer
Cyclophosphamide (anhydrous) developmental, female, male
Cyclophosphamide (hydrated) cancer
Cyclophosphamide (hydrated) developmental, female, male
Cyhexatin developmental
Cytarabine developmental
Cytembena cancer
D&C Orange No. 17 cancer
D&C Red No. 8 cancer
D&C Red No. 9 cancer
D&C Red No. 19 cancer
Dacarbazine cancer
Dacarbazine developmental
Daminozide cancer
Danazol developmental
Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone) cancer
Daunomycin cancer
Daunorubicin hydrochloride developmental
2,4-D butyric acid [Click here for the basis for the removal of developmental endpoint, effective June 22, 2001] developmental,     male
DDD (Dichlorodiphenyl-dichloroethane) cancer
DDE (Dichlorodiphenyl-dichloroethylene) cancer
DDT (Dichlorodiphenyl-trichloroethane) cancer
o,p’-DDT developmental, female, male
p,p’-DDT developmental, female, male
DDVP (Dichlorvos) cancer
2,4-DP (dichloroprop) Delisted January 25, 2002 [Click here for the basis for delisting] developmental
Demeclocycline hydrochloride (internal use) developmental
N,N’-Diacetylbenzidine cancer
2,4-Diaminoanisole cancer
2,4-Diaminoanisole sulfate cancer
4,4′-Diaminodiphenyl ether (4,4′-Oxydianiline) cancer
2,4-Diaminotoluene cancer
Diaminotoluene (mixed) cancer
Diazepam developmental
Diazoaminobenzene cancer
Diazoxide developmental
Dibenz[a,h]acridine cancer
Dibenz[a,j]acridine cancer
Dibenzanthracenes cancer
Dibenz[a,c]anthracene cancer
Dibenz[a,h]anthracene cancer
Dibenz[a,j]anthracene cancer
7H-Dibenzo[c,g]carbazole cancer
Dibenzo[a,e]pyrene cancer
Dibenzo[a,h]pyrene cancer
Dibenzo[a,i]pyrene cancer
Dibenzo[a,l]pyrene cancer
Dibromoacetic acid cancer
Dibromoacetonitrile cancer
1,2-Dibromo-3-chloropropane (DBCP) cancer
1,2-Dibromo-3-chloropropane (DBCP) [Basis for listing changed effective November 22, 2013] male
2,3-Dibromo-1-propanol cancer
Dichloroacetic acid cancer
Dichloroacetic acid developmental, male
p-Dichlorobenzene cancer
3,3′-Dichlorobenzidine cancer
3,3′-Dichlorobenzidine dihydrochloride cancer
1,1-Dichloro-2,2-bis(p-chloropheny)ethylene (DDE) developmental, male
1,4-Dichloro-2-butene cancer
3,3′-Dichloro-4,4′-diamino-diphenyl ether cancer
1,1-Dichloroethane cancer
Dichloromethane (Methylene chloride) cancer
Dichlorophene developmental
Dichlorphenamide developmental
1,2-Dichloropropane cancer
1,3-Dichloro-2-propanol (1,3-DCP) cancer
1,3-Dichloropropene cancer
Diclofop-methyl cancer
Diclofop methyl developmental
Dicumarol developmental
Dieldrin cancer
Dienestrol Delisted January 4, 2013 [Click here for the basis for delisting] cancer
Diepoxybutane cancer
Diesel engine exhaust cancer
Diethanolamine cancer
Di(2-ethylhexyl)phthalate cancer
Di(2-ethylhexyl)phthalate developmental, male
   Infant boys, age 29 days to 24 monthsb
   Neonatal infant boys, age 0 to 28 daysb
   Infant boys, age 29 days to 24 monthsb
   Neonatal infant boys, age 0 to 28 daysb
1,2-Diethylhydrazine cancer
Diethylstilbestrol (DES) cancer
Diethylstilbestrol (DES) developmental
Diethyl sulfate cancer
Diflunisal developmental, female
Diglycidyl ether Delisted April 4, 2014 [Click here for the basis for delisting] male
Diglycidyl resorcinol ether (DGRE) cancer
Dihydroergotamine mesylate developmental
Dihydrosafrole cancer
Diisononyl phthalate (DINP) cancer
Diisopropyl sulfate cancer
Di-isodecyl phthalate (DIDP) developmental
Diltiazem hydrochloride developmental
3,3′-Dimethoxybenzidine (o-Dianisidine) cancer
3,3′-Dimethoxybenzidine dihydrochloride cancer
3,3′-Dimethoxybenzidine-based dyes metabolized to 3,3′-dimethoxybenzidine cancer
N,N-Dimethylacetamide [Click here for the basis for addition of male reproductive endpoint, effective December 20, 2013] developmental, male
4-Dimethylaminoazobenzene cancer
trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2-furyl)vinyl]-1,3,4-oxadiazole cancer
7,12-Dimethylbenz(a)anthracene cancer
3,3′-Dimethylbenzidine (ortho-Tolidine) cancer
3,3′-Dimethylbenzidine dihydrochloride cancer
3,3′-Dimethylbenzidine-based dyes metabolized to 3,3′-dimethylbenzidine cancer
Dimethylcarbamoyl chloride cancer
1,1-Dimethylhydrazine (UDMH) cancer
1,2-Dimethylhydrazine cancer
2,6-Dimethyl-N-nitrosomorpholine (DMNM) cancer
Dimethyl sulfate cancer
N,N-Dimethyl-p-toluidine cancer
Dimethylvinylchloride cancer
Di-n-butyl phthalate (DBP) developmental, female, male
Di-n-hexyl phthalate (DnHP) female, male
m-Dinitrobenzene male
o-Dinitrobenzene male
p-Dinitrobenzene male
3,7-Dinitrofluoranthene cancer
3,9-Dinitrofluoranthene cancer
1,3-Dinitropyrene cancer
1,6-Dinitropyrene cancer
1,8-Dinitropyrene cancer
2,4-Dinitrotoluene cancer
2,4-Dinitrotoluene male
2,6-Dinitrotoluene cancer
2,6-Dinitrotoluene male
Dinitrotoluene (technical grade) female, male
Dinitrotoluene mixture, 2,4-/2,6- cancer
Dinocap developmental
Dinoseb developmental, male
Di-n-propyl isocinchomeronate (MGK Repellent 326) cancer
1,4-Dioxane cancer
Diphenylhydantoin (Phenytoin) cancer
Diphenylhydantoin (Phenytoin) developmental
Diphenylhydantoin (Phenytoin), sodium salt cancer
Direct Black 38 (technical grade) cancer
Direct Blue 6 (technical grade) cancer
Direct Brown 95 (technical grade) cancer
Disodium cyanodithioimidocarbonate developmental
Disperse Blue 1 cancer
Diuron cancer
Doxorubicin hydrochloride (Adriamycin) cancer
Doxorubicin hydrochloride (Adriamycin) developmental, male
Doxycycline (internal use) developmental
Doxycycline calcium (internal use) developmental
Doxycycline hyclate (internal use) developmental
Doxycycline monohydrate (internal use) developmental
Emissions from combustion of coal cancer
Emissions from high-temperature unrefined rapeseed oil cancer
Endrin developmental
Environmental tobacco smoke (ETS) developmental
Epichlorohydrin cancer
Epichlorohydrin male
Epoxiconazole cancer
Ergotamine tartrate developmental
Erionite cancer
Estradiol 17B cancer
Estragole cancer
Estrogens, steroidal cancer
Estrogen-progestogen (combined) used as menopausal therapy cancer
Estrone cancer
Estropipate cancer, developmental
Ethanol in alcoholic beverages cancer
Ethinylestradiol cancer
Ethionamide developmental
Ethoprop cancer
Ethyl acrylate cancer
Ethyl alcohol in alcoholic beverages developmental
Ethylbenzene cancer
Ethyl-tert-butyl ether Delisted December 13, 2013 [Clik here for the basis for delisting] male
Ethyl dipropylthiocarbamate developmental
Ethyl-4,4′-dichlorobenzilate cancer
Ethylene dibromide cancer
Ethylene dibromide developmental, male
Ethylene dichloride (1,2-Dichloroethane) cancer
Ethylene glycol monoethyl ether developmental, male
Ethylene glycol monoethyl ether acetate developmental, male
Ethylene glycol monomethyl ether developmental, male
Ethylene glycol monomethyl ether acetate developmental, male
Ethyleneimine cancer
Ethylene oxide cancer
Ethylene oxide [Basis for listing changed effective November 22, 2013] female
Ethylene oxide [Basis for listing changed effective November 22, 2013] developmental, male
Ethylene thiourea cancer
Ethylene thiourea developmental
2-Ethylhexanoic acid Delisted December 13, 2013 [Click here for the basis for delisting] developmental
Ethyl methanesulfonate cancer
Etodolac developmental, female
Etoposide cancer
Etoposide developmental
Etoposide in combination with cisplatin and bleomycin cancer
Etretinate developmental
Fenoxaprop ethyl developmental
Fenoxycarb cancer
Filgrastim developmental
Fluazifop butyl developmental
Flunisolide developmental, female
Fluorouracil developmental
Fluoxymesterone developmental
Flurazepam hydrochloride developmental
Flurbiprofen developmental, female
Flutamide developmental
Fluticasone propionate developmental
Fluvalinate developmental
Folpet cancer
Formaldehyde (gas) cancer
2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole cancer
Fumonisin B1 cancer
Furan cancer
Furazolidone cancer
Furmecyclox cancer
Fusarin C cancer
Gallium arsenide cancer
Ganciclovir cancer, developmental, male
Ganciclovir sodium developmental, male
Gasoline engine exhaust (condensates/extracts) cancer
Gemfibrozil cancer
Gemfibrozil female, male
Glass wool fibers (inhalable and biopersistent) cancer
Glu-P-1 (2-Amino-6-methyldipyrido[1,2- a:3′,2′-d]imidazole) cancer
Glu-P-2 (2-Aminodipyrido[1,2-a:3′,2′-d]imidazole) cancer
Glycidaldehyde cancer
Glycidol cancer
Goserelin acetate developmental, female, male
Griseofulvin cancer
Gyromitrin (Acetaldehyde methylformylhydrazone) cancer
Halazepam developmental
Halobetasol propionate developmental
Haloperidol developmental, female
Halothane developmental
HC Blue 1 cancer
Heptachlor cancer
Heptachlor developmental
Heptachlor epoxide cancer
Herbal remedies containing plant species of the genus Aristolochia cancer
Hexachlorobenzene cancer
Hexachlorobenzene developmental
Hexachlorobutadiene cancer
Hexachlorocyclohexane (technical grade) cancer
   Hexachlorocyclohexane (alpha isomer)
   Hexachlorocyclohexane (beta isomer)
   Hexachlorocyclohexane (gamma isomer)
Hexachlorodibenzodioxin cancer
Hexachloroethane cancer
2,4-Hexadienal (89% trans, trans isomer; 11% cis, trans isomer) cancer
Hexafluoroacetone [Basis for listing changed effective June 6, 2014] developmental, male
Hexamethylphosphoramide cancer
Hexamethylphosphoramide male
Histrelin acetate developmental
Hydramethylnon developmental, male
Hydrazine cancer
Hydrazine sulfate cancer
Hydrazobenzene (1,2-Diphenylhydrazine) cancer
Hydrogen cyanide (HCN) and cyanide salts (CN salts) male
Cyanide salts that readily dissociate in solution (expressed as cyanide)f
Hydrogen cyanidef
Sodium cyanidef
Potassium cyanidef
1-Hydroxyanthraquinone cancer
Hydroxyurea developmental
Idarubicin hydrochloride developmental, male
Ifosfamide developmental
Iodine-131 developmental
Imazalil cancer
Indeno [1,2,3-cd]pyrene cancer
Indium phosphide cancer
IQ (2-Amino-3-methylimidazo[4,5-f] quinoline) cancer
Iprodione cancer
Iprovalicarb cancer
Iron dextran complex cancer
Isobutyl nitrite cancer
Isoprene cancer
Isopyrazam cancer
Isosafrole Delisted December 8, 2006 [Click here for the basis for delisting] cancer
Isotretinoin developmental
Isoxaflutole cancer
Kresoxim-methyl cancer
Lactofen cancer
Lasiocarpine cancer
Lead [Basis for listing changed effective November 22, 2013] developmental, female, male
Lead and lead compounds cancer
Lead acetate cancer
Lead phosphate cancer
Lead subacetate cancer
Leather dust cancer
Leuprolide acetate developmental, female, male
Levodopa developmental
Levonorgestrel implants female
Lindane and other hexachlorocyclohexane isomers cancer
Linuron developmental
Lithium carbonate developmental
Lithium citrate developmental
Lorazepam developmental
Lovastatin developmental
Lynestrenol cancer
Malonaldehyde, sodium salt cancer
Mancozeb cancer
Maneb cancer
Marijuana smoke cancer
Me-A-alpha-C (2-Amino-3-methyl-9H-pyrido[2,3-b]indole) cancer
Mebendazole developmental
Medroxyprogesterone acetate cancer
Medroxyprogesterone acetate developmental
Megestrol acetate cancer
Megestrol acetate developmental
MeIQ (2-Amino-3,4-dimethylimidazo[4,5-f]quinoline) cancer
MeIQx (2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline) cancer
Melphalan cancer
Melphalan developmental
Menotropins developmental
Mepanipyrim cancer
Meprobamate developmental
Mercaptopurine developmental
Mercury and mercury compounds developmental
Merphalan cancer
Mestranol cancer
Metam potassium cancer
Methacycline hydrochloride developmental
Metham sodium cancer
Metham sodium developmental
Methanol developmental
Methazole developmental
Methimazole developmental
Methotrexate developmental
Methotrexate sodium developmental
5-Methoxypsoralen with ultraviolet A therapy cancer
8-Methoxypsoralen with ultraviolet A therapy cancer
2-Methylaziridine (Propyleneimine) cancer
Methylazoxymethanol cancer
Methylazoxymethanol acetate cancer
Methyl bromide, as a structural fumigant developmental
Methyl n-butyl ketone male
Methyl carbamate cancer
Methyl chloride developmental
Methyl chloride [Basis for listing changed effective March 7, 2014] male
3-Methylcholanthrene cancer
5-Methylchrysene cancer
4,4′-Methylene bis(2-chloroaniline) cancer
4,4′-Methylene bis(N,N-dimethyl)benzenamine cancer
4,4′-Methylene bis(2-methylaniline) cancer
4,4′-Methylenedianiline cancer
4,4′-Methylenedianiline dihydrochloride cancer
Methyleugenol cancer
Methylhydrazine and its salts cancer
   Methylhydrazine sulfate
2-Methylimidazole cancer
4-Methylimidazole cancer
Methyl iodide cancer
Methyl isobutyl ketone cancer
Methyl isobutyl ketone (MIBK) developmental
Methyl isocyanate (MIC) developmental, female
Methyl isopropyl ketone Delisted April 4, 2014 [Click for the basis for delisting] developmental
Methyl mercury developmental
Methylmercury compounds cancer
Methyl methanesulfonate cancer
2-Methyl-1-nitroanthraquinone (of uncertain purity) cancer
N-Methyl-N’-nitro-N-nitrosoguanidine cancer
N-Methylolacrylamide cancer
N-Methylpyrrolidone developmental
α-Methyl styrene (alpha-Methylstyrene) cancer
α-Methyl styrene Delisted April 4, 2014 [Click for the basis for delisting] female
Methyltestosterone developmental
Methylthiouracil cancer
Metiram cancer
Metiram developmental
Metronidazole cancer
Michler’s ketone cancer
Midazolam hydrochloride developmental
Minocycline hydrochloride (internal use) developmental
Mirex cancer
Misoprostol developmental
Mitomycin C cancer
Mitoxantrone hydrochloride cancer
Mitoxantrone hydrochloride developmental
Molinate developmental, female, male
MON 4660 (dichloroacetyl-1-oxa-4-azaspiro(4,5)-decane cancer
MON 13900 (furilazole) cancer
3-Monochloropropane-1,2-diol (3-MCDP) cancer
Monocrotaline cancer
MOPP (vincristine-prednisone-nitrogen mustard-procarbazine mixture) cancer
5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)-amino]-2-oxazolidinone cancer
Mustard Gas cancer
MX (3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone) cancer
Myclobutanil developmental, male
Nabam developmental
Nafarelin acetate developmental
Nafenopin cancer
Nalidixic acid cancer
Naphthalene cancer
1-Naphthylamine cancer
2-Naphthylamine cancer
Neomycin sulfate (internal use) developmental
Netilmicin sulfate developmental
Nickel (Metallic) cancer
Nickel acetate cancer
Nickel carbonate cancer
Nickel carbonyl cancer
Nickel carbonyl developmental
Nickel compounds cancer
Nickel hydroxide cancer
Nickelocene cancer
Nickel oxide cancer
Nickel refinery dust from the pyrometallurgical process cancer
Nickel subsulfide cancer
Nicotine developmental
Nifedipine developmental, female, male
Nimodipine developmental
Niridazole cancer
Nitrapyrin cancer
Nitrapyrin developmental
Nitrilotriacetic acid cancer
Nitrilotriacetic acid, trisodium salt monohydrate cancer
5-Nitroacenaphthene cancer
5-Nitro-o-anisidine Delisted December 8, 2006 [Click here for the basis for delisting] cancer
o-Nitroanisole cancer
Nitrobenzene cancer
Nitrobenzene male
4-Nitrobiphenyl cancer
6-Nitrochrysene cancer
Nitrofen (technical grade) cancer
2-Nitrofluorene cancer
Nitrofurantoin male
Nitrofurazone cancer
1-[(5-Nitrofurfurylidene)-amino]-2-imidazolidinone cancer
N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide cancer
Nitrogen mustard (Mechlorethamine) cancer
Nitrogen mustard (Mechlorethamine) developmental
Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) cancer
Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) developmental
Nitrogen mustard N-oxide cancer
Nitrogen mustard N-oxide hydrochloride cancer
Nitromethane cancer
2-Nitropropane cancer
1-Nitropyrene cancer
4-Nitropyrene cancer
N-Nitrosodiethanolamine cancer
N-Nitrosodiethylamine cancer
N-Nitrosodimethylamine cancer
N-Nitrosodi-n-butylamine cancer
N-Nitrosodi-n-propylamine cancer
p-Nitrosodiphenylamine cancer
N-Nitrosodiphenylamine cancer
3-(N-Nitrosomethylamino) propionitrile cancer
4-(N-Nitrosomethylamino)-1-(3-pyridyl)1-butanone cancer
N-Nitrosomethyl-n-butylamine cancer
N-Nitrosomethyl-n-decylamine cancer
N-Nitrosomethyl-n-dodecylamine cancer
N-Nitrosomethylethylamine cancer
N-Nitrosomethyl-n-heptylamine cancer
N-Nitrosomethyl-n-hexylamine cancer
N-Nitrosomethyl-n-nonylamine cancer
N-Nitrosomethyl-n-octylamine cancer
N-Nitrosomethyl-n-pentylamine cancer
N-Nitrosomethyl-n-propylamine cancer
N-Nitrosomethyl-n-tetradecylamine cancer
N-Nitrosomethyl-n-undecylamine cancer
N-Nitrosomethylvinylamine cancer
N-Nitrosomorpholine cancer
N-Nitroso-N-ethylurea cancer
N-Nitroso-N-methylurea cancer
N-Nitroso-N-methylurethane cancer
N-Nitrosonornicotine cancer
N-Nitrosopiperidine cancer
N-Nitrosopyrrolidine cancer
N-Nitrososarcosine cancer
o-Nitrotoluene cancer
Nitrous oxide [Basis for listing changed effective November 8, 2013] developmental, female
Norethisterone (Norethindrone) cancer
Norethisterone (Norethindrone) developmental
Norethisterone acetate (Norethindrone acetate) developmental
Norethisterone (Norethindrone) /Ethinyl estradiol developmental
Norethisterone (Norethindrone) /Mestranol developmental
Norethynodrel cancer
Norgestrel developmental
Ochratoxin A cancer
Oil Orange SS cancer
Oral contraceptives, combined cancer
Oral contraceptives, sequential cancer
Oryzalin cancer
Oxadiazon cancer
Oxadiazon developmental
Oxazepam cancer
Oxazepam developmental
p,p’-Oxybis(benzenesulfonyl hydrazide) Delisted December 13, 2013 [Click here for the basis for delisting] developmental
Oxydemeton methyl female, male
Oxymetholone cancer
Oxymetholone developmental
Oxytetracycline (internal use) developmental
Oxytetracycline hydrochloride (internal use) developmental
Oxythioquinox (Chinomethionat) cancer
Oxythioquinox (Chinomethionat) developmental
Paclitaxel developmental, female, male
Palygorskite fibers (> 5mm in length) cancer
Panfuran S cancer
Paramethadione developmental
Penicillamine developmental
Pentachlorophenol cancer
Pentobarbital sodium developmental
Pentosan polysulfate sodium cancer
Pentostatin developmental
Phenacemide developmental
Phenacetin cancer
Phenazopyridine cancer
Phenazopyridine hydrochloride cancer
Phenesterin cancer
Phenobarbital cancer
Phenolphthalein cancer
Phenoxybenzamine cancer
Phenoxybenzamine hydrochloride cancer
Phenprocoumon developmental
o-Phenylenediamine and its salts cancer
   o-Phenylenediamine dihydochloride
Phenyl glycidyl ether cancer
Phenyl glycidyl ether male
Delisted April 4, 2014 [Click here
for the basis for delisting]
Phenylhydrazine and its salts cancer
   Phenylhydrazine hydrochloride
o-Phenylphenate, sodium cancer
o-Phenylphenol cancer
Phenylphosphine [Basis for listing changed effective June 6, 2014] developmental male
PhiP(2-Amino-1-methyl-6-phenylimidazol[4,5-b]pyridine) cancer
Pimozide developmental, female
Pioglitazone cancer
Pipobroman developmental
Pirimicarb cancer
Plicamycin developmental
Polybrominated biphenyls cancer
Polybrominated biphenyls developmental
Polychlorinated biphenyls cancer
Polychlorinated biphenyls developmental
Polychlorinated biphenyls (containing 60 or more percent percent chlorine by molecular weight) cancer
Polychlorinated dibenzo-p-dioxins cancer
Polychlorinated dibenzofurans cancer
Polygeenan cancer
Ponceau MX cancer
Ponceau 3R cancer
Potassium bromate cancer
Potassium dimethyldithiocarbamate developmental
Pravastatin sodium developmental
Prednisolone sodium phosphate developmental
Primidone cancer
Procarbazine cancer
Procarbazine hydrochloride cancer
Procarbazine hydrochloride developmental
Procymidone cancer
Progesterone cancer
Pronamide cancer
Propachlor cancer
1,3-Propane sultone cancer
Propargite cancer
Propargite developmental
beta-Propiolactone cancer
Propoxur cancer
Propylene glycol mono-t-butyl ether cancer
Propylene oxide cancer
Propylthiouracil cancer
Propylthiouracil developmental
Pulegone cancer
Pymetrozine cancer
Pyridine cancer
Pyrimethamine developmental
Quazepam developmental
Quinoline and its strong acid salts cancer
Quizalofop-ethyl male
Radionuclides cancer
Reserpine cancer
Residual (heavy) fuel oils cancer
Resmethrin cancer
Resmethrin developmental
Retinol/retinyl esters, when in daily dosages in excess of 10,000 IU, or 3,000 retinol equivalents. (NOTE: Retinol/retinyl esters are required and essential for maintenance of normal reproductive function. The recommended daily level during pregnancy is 8,000 IU.) developmental
Ribavirin developmental
Ribavirin male
Riddelliine cancer
Rifampin developmental, female
Saccharin   Delisted April 6, 2001   [Click here for the basis for delisting] cancer
Saccharin, sodium Delisted January 17, 2003 [Click here for the basis for delisting] cancer
Safrole cancer
Salted fish, Chinese-style cancer
Secobarbital sodium developmental
Selenium sulfide cancer
Sermorelin acetate developmental
Shale-oils cancer
Silica, crystalline (airborne particles of respirable size) cancer
Sodium dimethyldithiocarbamate developmental
Sodium fluoroacetate male
Soots, tars, and mineral oils (untreated and mildly treated oils and used engine oils) cancer
Spirodiclofen cancer
Spironolactone cancer
Stanozolol cancer
Sterigmatocystin cancer
Streptomycin sulfate developmental
Streptozocin (streptozotocin) developmental, female, male
Streptozotocin (streptozocin) cancer
Strong inorganic acid mists containing sulfuric acid cancer
Styrene oxide cancer
Sulfallate cancer
Sulfasalazine (salicylazosulfapyridine) cancer
Sulfasalazine (salicylazosulfapyridine) male
Sulfur dioxidee developmental
Sulindac developmental, female
Talc containing asbestiform fibers cancer
Tamoxifen and its salts cancer
Tamoxifen citrate developmental
Temazepam developmental
Teniposide developmental
Terbacil developmental
Terrazole cancer
Testosterone and its esters cancer
Testosterone cypionate developmental
Testosterone enanthate developmental
3,3′,4,4′-Tetrachloroazobenzene cancer
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) cancer
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) developmental
1,1,1,2-Tetrachloroethane cancer
1,1,2,2-Tetrachloroethane cancer
Tetrachloroethylene (Perchloroethylene) cancer
p-a,a,a-Tetrachlorotoluene cancer
Tetracycline (internal use) developmental
Tetracyclines (internal use) developmental
Tetracycline hydrochloride (internal use) developmental
Tetrafluoroethylene cancer
Tetranitromethane cancer
Thalidomide developmental
Thioacetamide cancer
4,4′-Thiodianiline cancer
Thiodicarb cancer
Thioguanine developmental
Thiophanate methyl female, male
Thiouracil cancer
Thiourea cancer
Thorium dioxide cancer
Titanium dioxide (airborne, unbound particles of respirable size) cancer
Tobacco, oral use of smokeless products cancer
Tobacco smoke cancer
Tobacco smoke (primary) developmental, female, male
Tobramycin sulfate developmental
Toluene developmental
Toluene [Click here for the basis for the removal of female reproductive endpoint effective March 7, 2014] female
Toluene diisocyanate cancer
o-Toluidine cancer
o-Toluidine hydrochloride cancer
para-Toluidine Delisted October 29, 1999 [Click here for the basis for delisting] cancer
Toxaphene (Polychlorinated camphenes) cancer
Toxins derived from Fusarium moniliforme (Fusarium verticillioides) cancer
Treosulfan cancer
Triadimefon developmental, female, male
Triamterene cancer
Triazolam developmental
S,S,S-Tributyl phosphorotrithioate (Tribufos, DEF) cancer
Tributyltin methacrylate developmental
Trichlormethine (Trimustine hydrochloride) cancer
Trichloroacetic acid cancer
Trichloroethylene cancer
Trichloroethylene developmental, male
2,4,6-Trichlorophenol cancer
1,2,3-Trichloropropane cancer
Trientine hydrochloride developmental
Triforine developmental
1,3,5-Triglycidyl-s-triazinetrione Delisted December 13, 2013 [Click here for the basis for delisting] male
Trilostane developmental
Trimethadione developmental
2,4,5-Trimethylaniline and its strong acid salts cancer
Trimethyl phosphate cancer
Trimetrexate glucuronate developmental
2,4.6-Trinitrotoluene (TNT) cancer
Triphenyltin hydroxide cancer
Triphenyltin hydroxide developmental
Tris(aziridinyl)-p-benzoquinone (Triaziquone) Delisted December 8, 2006 [Click here for the basis for delisting] cancer
Tris(1-aziridinyl)phosphine sulfide (Thiotepa) cancer
Tris(2-chloroethyl) phosphate cancer
Tris(2,3-dibromopropyl)phosphate cancer
Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) cancer
Trp-P-1 (Tryptophan-P-1) cancer
Trp-P-2 (Tryptophan-P-2) cancer
Trypan blue (commercial grade) cancer
Unleaded gasoline (wholly vaporized) cancer
Uracil mustard cancer
Uracil mustard developmental, female, male
Urethane (Ethyl carbamate) cancer
Urethane (Ethyl carbamate) developmental
Urofollitropin developmental
Valproate (Valproic acid) developmental
Vanadium pentoxide (orthorhombic crystalline form) cancer
Vinblastine sulfate developmental
Vinclozolin cancer
Vinclozolin developmental
Vincristine sulfate developmental
Vinyl bromide cancer
Vinyl chloride cancer
4-Vinylcyclohexene cancer
4-Vinylcyclohexene [Click here for the basis for the removal of male reproductive endpoint, effective December 20, 2013 ] female, male
4-Vinyl-1-cyclohexene diepoxide (Vinyl cyclohexenedioxide) cancer
Vinyl cyclohexene dioxide (4-Vinyl-1-cyclohexene diepoxide) [Click here for the basis for the removal of male reproductive endpoint, effective December 20, 2013] female, male
Vinyl fluoride cancer
Vinyl trichloride (1,1,2-Trichloroethane) cancer
Warfarin developmental
Wood dust cancer
2,6-Xylidine (2,6-Dimethylaniline) cancer
Zalcitabine cancer
Zidovudine (AZT) cancer
Zileuton cancer, developmental, female
Zineb Delisted October 29, 1999 [Click here for the basis for delisting] cancer